Fruits - Vegetables - Meats - Poultry - Fish

Fresh n' Clean
All Natural Super Concentrate Wash Aid
For Fruits, Vegetables, Meats, Poultry, and Fish

Male Infertility and Glutathione


Are You Half The Man Your Father Was?

It is a well-known fact that sperm counts have dropped by half in the last 50 years, and that modern men have 20 percent less semen volume than their fathers (BMJ, 1992, volume 305).

A recent report from researchers in Aberdeen presented preliminary data that suggests the sperm concentration of the men seen in their clinic had declined by 29% over the past 14 years. (British Fertility Society; 5 January 2004)

Persistent organic pollutants (POPs) and endocrine-disrupting chemicals from normal, everyday plastics are known to cause reproductive damage, as documented in Theo Colborn's book "Our Stolen Future."

Damage to sperm caused by exposure to common chemicals like alcohol, pesticides in food, has been linked to lowered intelligence and behavioral disorders in children.

Lifestyle risk factors known to decrease sperm quality include

> Cigarette smoking

> Alcohol consumption

> Chronic stress

> Nutritional deficiencies.

Other reasons for infertility include congenital factors, and health conditions like prostatitis and diabetes that can affect sperm production.

Pollution is stealing our future, and there's little anyone can do to avoid it. There may not be a lot you can do to reduce your exposure to persistent environmental toxins.

But there are definite measures you can take to reduce the impact of the environmental pollutants and toxins on your body.

You can prevent and, to a certain extent, repair the damage they cause to your body, through a better lifestyle and nutrition.

Some nutritional therapies and antioxidants that have proven beneficial in treating male infertility and improving sperm counts, sperm morphology and motility include:

> Carnitine

> Arginine

> Zinc

> Selenium

> Vitamin B-12

> Vitamin C

> Vitamin E

> Glutathione

> Coenzyme Q10

Studies show that anti-oxidant supplementation - glutathione in particular - can improve sperm quality, and possibly increase your chances of conceiving.

If you smoke, drink, are exposed to stress, chemicals, radiation, pesticides or take medication or drugs (like sulfasalazine, ketoconazole, azulfidine, anabolic steroids, marijuana) that affect fertility, you should consider taking an antioxidant supplement to reverse some of the damage.

Why are Antioxidants Important for Sperm Quality?

Mammalian spermatozoa are coated by a membrane rich in polyunsaturated fatty acids. These fatty acids are extremely susceptible to oxidative damage by free radicals or Reactive Oxygen Species (ROS) by a process called lipid peroxidation (LPO).

Lipid peroxidation damages the sperm cell membrane. It is considered to be the key mechanism of ROS-induced sperm damage and leads to

> Loss of sperm motility

> Abnormal sperm morphology

> Reduced capacity for oocyte penetration

> Infertility

To protect sperm from damage, the body depends on powerful antioxidant enzymes in the body such as superoxide dismutase (SOD), catalase, and glutathione peroxidase/reductase (GPX/GRD).

Seminal plasma and spermatozoa have several antioxidant enzymes - glutathione peroxidase, glutathione reductase, superoxide dismutase.

Some amount of all the antioxidant enzymes, which may protect spermatozoa from oxidative attack, are also made by the epididymis during storage.

The glutathione peroxidase/reductase enzymes play a central role in the defense against oxidative damage in human sperm.

Why is Glutathione important for Sperm Quality and Fertility?

A decrease in levels of reduced glutathione (GSH) during sperm production is known to disrupt the membrane integrity of spermatozoa due to increased oxidative stress.

Intracellular glutathione levels of spermatozoa are known to be decreased in certain populations of infertile men. Compared with a control group, the infertile men in all groups had significantly higher levels of ROS and lower levels of total antioxidants.

There is strong clinical evidence to show that men diagnosed with infertility have high levels of oxidative stress that may impair the quality of their sperm.

In some groups, higher levels of ROS were associated with lower sperm counts and defective sperm structure, while lower antioxidant levels correlated with reduced sperm movement.

Previous evidence has also shown that oxidative stress can decrease a sperm's life span, its motility, and its ability to penetrate the oocyst, or egg cell.

Up to 40% of men with unexplained male infertility have higher levels of free radical activity in their bodies.

Because men with high levels of ROS have a seven-fold lower likelihood of inducing a pregnancy than men with lower levels, researchers recommend that treatment for infertile men should include strategies to reduce oxidative stress and improve sperm quality.

How can Glutathione help in the Treatment of Infertility?

Glutathione is not only vital to sperm antioxidant defenses, but selenium and glutathione are essential to the formation of "phospholipid hydroperoxide glutathione peroxidase" - an enzyme present in spermatids - which becomes a structural protein in the mid-piece of mature spermatozoa.

When either substance is deficient, it can lead to instability of the mid-piece of the spermatozoa, resulting in defective motility.

Free radical scavengers - such as glutathione - that restore the structure and function of poly-unsaturated fatty acids (PUFA) in the cell membrane, can be used to treat these cases.

In a double-blind cross-over study of twenty infertile men, treatment with glutathione led to a statistically significant improvement of the sperm quality.

The study concerned men in whom the sperm quality was poor due to unilateral varicocele or germ-free genital tract inflammation - two conditions in which ROS or other toxic compounds are indicated as causative factors.

Treatment with glutathione was also found to have a statistically significantly positive effect on sperm motility (in particular forward motility) and on sperm morphology.

The findings of these studies indicate that glutathione therapy could represent a possible therapeutical tool in cases where ROS or exposure to toxins is the probable cause of infertility.

Read the complete report with references on Male Infertility and Glutathione

Copyright 2004 Priya Shah

_____________________________________________

About the author:
Priya Shah is the Editor of The Glutathione Report, a newsletter featuring regular updates on the health benefits of glutathione. Get a Free report on Glutathione in Health and Disease
____________________________________________


MORE RESOURCES:
This RSS feed URL is deprecated, please update. New URLs can be found in the footers at https://news.google.com/news


FDA drops committee on food safety, nutrition | Packer
The Packer
The Food and Drug Administration has disbanded the Food Advisory Committee, which provides advice to the agency on food safety, nutrition and other issues. The committee, established in 1992, has met only a handful of time in recent years, the last ...

and more »


CU Boulder Today

Nutrition counseling for employees during winter break
CU Boulder Today
Interested in changing your diet, getting guidance on personal nutrition goals, or body-composition testing? Make an appointment during winter break with Nutrition Services, located on the third floor of the Wardenburg Health Center. They have two ...



Lynden Tribune

Community center meals provide nutrition, socialization
Lynden Tribune
“Let the community know that this is a nice opportunity for good nutrition and socializing,” he said. Sometimes McKenzie, when he is finished with his chef skills in the kitchen, will move to the piano to lead the entertainment. The daily hot meals ...



Sunbury Daily Item

Health 2018: For better nutrition, cut excuses before calories
Sunbury Daily Item
Dayton pointed out most gyms in the area have information on nutrition through classes at the start of the new year. Many opportunities to learn about nutrition or simply find healthy recipes are available through social media and online. For those ...



UKNow (press release)

UK Dietetics and Human Nutrition Students 'Plate Up' Healthy Recipes
UKNow (press release)
LEXINGTON, Ky. (Dec. 13, 2017) — Recently, students in a University of Kentucky Department of Dietetics and Human Nutrition class got the chance to create healthier recipes and serve them to panelists that included some Kentucky celebrities. Taught by ...



Harborcountry News

Blessings in a Backpack joins efforts to boost nutrition in Bridgman Schools
Harborcountry News
Blessings in a Backpack joins efforts to boost nutrition in Bridgman Schools. By David Johnson News Editor; Dec 11, 2017 Updated 11 hrs ago; 0 · Facebook · Twitter · Email. Helping Out. Sisters Jada and Carley Rudolph (from left) help pack Bridgman ...

and more »


Vitafoods Europe to Tackle the Personalized Nutrition Challenge
Natural Products INSIDER
How can personalized nutrition break out of its niche and achieve mass market appeal? This will be one of the major questions tackled at next year's Vitafoods Europe, which returns to Palexpo, Geneva between 15 and 17 May 2018. Advances in genomics and ...



Southernminn.com

Tanner Lange, intern with district's nutrition services dept., discusses healthy eating with second graders at Wilson
Southernminn.com
Tanner Lange, an intern with the Owatonna school district's nutrition services department, helped second graders at Wilson Elementary understand the importance of healthy eating during a presentation Wednesday. (Ryan Anderson/People's Press). By RYAN ...



Plan to remove nutrition counsellors in anganwadis causes stir
The Hindu
“We protest the decision of the State government to remove the nutrition counsellors and link workers from the service. At a time when the health of pregnant women and infants are being cited as top priority of both the Central and State governments ...



Milwaukee Journal Sentinel

Breathe events
Milwaukee Journal Sentinel
Bay View Community Center: Healthy Eating, 6:30-9 p.m. Jan. 11. New series emphasizes healthy food choices and reducing fat and salt. 1320 E. Oklahoma Ave. (414) 482-1000; www.bayviewcenter.org. Good Harvest Market: Eat for Your Genes, 6:30 p.m. Dec ...


Google News

home | site map

© 2006 Global Biotechnologies, Inc.


MaineBannerExchange